HypoxyLab™ Hypoxia Workstation from Oxford Optronix Ltd.

Product Specs
ItemHypoxyLab™ Hypoxia Workstation
CompanyOxford Optronix Ltd.
Price Get Pricing Get Quote for this Product
Catalog NumberHYPOXYLAB
TypeBench-top hypoxia workstation
QuantityEA
External Dimensions(WxDxH) 590 x 690 x 800 mm
Electrical RequirementsAuto-switching 90 to 240 V AC, 50/60 Hz
Accuracy± 1 mmHg (Oxygen), ± 0.2 % (CO₂), ± 0.1 ºC (Temp), ± 2% (Relative Humidity)
Measuring Range0 to 140 mmHg (Oxygen), 0 to 20% (CO₂)
Dimensions(WxDxH) 590 x 690 x 800 mm
Capacity90 L (chamber)
TimeHypoxia in less than 20 minutes from switch-on
LightingInternal, user-controllable LED lighting
DisplayHigh contrast 800 x 480 LCD touch-screen
Humidity Range20 to 75 % RH (Ambient T = 20 °C)
Temperature RangeAmbient + 5ºC to 42ºC

Specifications/Features

Transfer hatch: Easy-entry letterbox

Oxygen Control: 0 to 160 mmHg (ambient)

Options: Dedicated OxyLite™ module for real-time oxygen measurements directly from cell-culture media

Gases: Air, Nitrogen, CO₂ (4 bar inlet pressure)

Chamber working area: Approx. 200 inch²

CO2 Control: 0 to 20%

Contamination Control: Integrated HEPA filtration

Data logging: Generic USB flash drive

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Oxford Optronix Ltd.

19 – 21 Central 127

127 Olympic Avenue

Milton Park, Abingdon OX14 4SA

United Kingdom

Phone: +44 (0)1235 821 803
Fax: +44 (0)1235 821 678

Email: sales@oxford-optronix.com
info@oxford-optronix.com
support@oxford-optronix.com

Company Profile

Website: www.oxford-optronix.com

(1) NanoFIRE: A NanoLuciferase and Fluorescent Integrated Reporter Element for Robust and Sensitive Investigation of HIF and Other Signalling PathwaysBiomoleculesOctober 19, 2023Alison E. Roennfeldt, Timothy P. Allen, Brooke N. Trowbridge, Michael R. Beard, Murray L. Whitelaw, Darryl L. Russell, David C. Bersten, Daniel J. Peetand stated as normalised NLU (NNLU). Hypoxic cell incubations were completed in the Oxford Optronix HypoxyLab at stated oxygen concentrations under humidified conditions at 37 °C and 5% CO2. 2.6. Primary Granulosa Cell

(2) Mathematical modelling with Bayesian inference to quantitatively characterize therapeutic cell behaviour in nerve tissue engineeringJournal of The Royal Society InterfaceSeptember 6, 2023Maxime Berg, Despoina Eleftheriadou, James B. Phillips, Rebecca J. Shipleyml−1. 2.1.2. Ambient oxygen control and local oxygen measurement A hypoxia workstation and incubator (HypoxyLab, Oxford Optronix, Oxford, UK) was used to control the ambient oxygen levels for the 24 h culture period

(3) Poison cassette exon splicing of SRSF6 regulates nuclear speckle dispersal and the response to hypoxiaNucleic acids researchJanuary 25, 2023de Oliveira Freitas Machado C, Schafranek M, Brüggemann M, Hernández Cañás MC, Keller M, Di Liddo A, Brezski A, Blümel N, Arnold B, Bremm A, et al.were grown in two replicates on 14 cm culture dishes in normoxia or 24 h hypoxia and harvested in a HypoxyLab station (Oxford Optronix, UK). For stringent IPs, 100 μl of beads (Dynabeads Protein G, Thermo Fisher

(4) Putative critical quality attribute matrix identifies mesenchymal stromal cells with potent immunomodulatory and angiogenic “fitness” ranges in response to culture process parametersFrontiers in ImmunologyNovember 30, 2022Kevin P. Robb, Julie Audet, Rajiv Gandhi, Sowmya Viswanathanincubator) or 2D-H conditions (38 mmHg O2, i.e., 5% O2 under standard atmospheric pressure) using a HypoxyLab workstation (Oxford Optronix, Milton, UK) for the same duration as 3D culture. Prior to experiments,

(5) In vitro radiosensitization of breast cancer with hypoxia-activated prodrugsJournal of cellular and molecular medicineAugust 1, 2022Aiyappa-Maudsley R, Elsalem L, Ibrahim AIM, Pors K, Martin SG.normoxic incubator (21% O2) for 3 h. Following attachment, cells for hypoxia experiments were placed in a HypoxyLab™ (Oxford Optronix) hypoxia workstation which was maintained at 1% O2 levels for 24 h. SW480‐2 W1 cells

(6) A combined experimental and computational framework to evaluate the behavior of therapeutic cells for peripheral nerve regenerationBiotechnology and BioengineeringJuly 1, 2022Despoina Eleftheriadou, Maxime Berg, James B. Phillips, Rebecca J. Shipleyin vivo. 2.3 Low oxygen 3D cell culture and oxygen monitoring A hypoxia workstation and incubator (HypoxyLab, Oxford Optronix) was used for experiments requiring low oxygen conditions. Cell culture medium for

(7) Impact of the acidic environment on gene expression and functional parameters of tumors in vitro and in vivoJournal of experimental & clinical cancer research : CRJanuary 6, 2021Rauschner M, Lange L, Hüsing T, Reime S, Nolze A, Maschek M, Thews O, Riemann A.cells with room air containing 5% CO2. Hypoxic culture conditions were induced in a hypoxia chamber (HypoxyLab, Oxford Optronix, Oxford, UK) at 0.2% O2 (pO2 = 1.5 mmHg) and 5% CO2. For analysis of mRNA and protein expression

(8) SMARCB1 Promotes Ubiquitination and Degradation of NR4A3 via Direct Interaction Driven by ROS in Vascular Endothelial Cell InjuryOxidative Medicine and Cellular LongevityOctober 23, 2020Bingzheng Lu et al.The hypoxia-related treatments were carried out using an oxygen-controlled hypoxic working station (HypoxyLab™, Oxford Optronix, UK) with 1% O2, 5% CO2, 90 ± 1% humidity (RH), and 37.0 ± 0.5°C temperature. Briefly,

(9) Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblastsScientific reportsMay 20, 2020Kozlov AM, Lone A, Betts DH, Cumming RC.for HIF-1α experiments, fibroblasts were maintained in the above culture medium and incubated in a HypoxyLab (Oxford Optronix) chamber at 5% CO2, 37 °C, 1% O2. Defined metabolite media were prepared as follows.

(10) Inhibition of Carbonic Anhydrase IX by Ureidosulfonamide Inhibitor U104 Reduces Prostate Cancer Cell Growth, But Does Not Modulate Daunorubicin or Cisplatin CytotoxicityOncology Research Featuring Preclinical and Clinical Cancer TherapeuticsMarch 5, 2018Anne Riemann, Antje Güttler, Verena Haupt, Henri Wichmann, Sarah Reime, Matthias Bache, Dirk Vordermark, Oliver Thewssupplementation for 24 h under normoxic or hypoxic conditions (0.2% O2, 5% CO2; hypoxia incubator; HypoxyLab; Oxford Optronix, Abingdon, UK) and subsequently incubated in bicarbonate-HEPES or -MES-buffered Ringer

(11) Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1Cell Chemical BiologyNovember 16, 2017Anurag Kulkarni, Manuel Mateus, Cyrille C. Thinnes, James S. McCullagh, Christopher J. Schofield, Graham P. Taylor, Charles R.M. Banghamcell culture with 10% FBS (Gibco) in all experiments, unless otherwise stated. Hypoxia Culture A ‘Hypoxylab’ (Oxford Optronix, Oxford, UK) - hypoxia workstation and incubator was employed for all hypoxia-related

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